Question

Shown below is a proposed mechanism for the cleavage of sialic acid by the viral enzyme neuraminidase. The kat for the wild-type enzyme at pH- 6.15, 37 Cis 26.8s-1 0 D149 OH OH 1st Step ROH R374 E117 117) +H2O ↓ 2nd Step Y409 0149 D149) OH OH OH R374 0 17) (E117) Part A Match the items in the left column to the appropriate bianks in the sestence on the right [Reset] [H삔 Glu117 Tyr4os Asp149 ads as a GAC in s one and as a GBC in shep three ach as GBC in step 2 and a GAC in stp

Answer 1

0 0 IntnlEp ov ル04一/ →尺LYo (r //t) DIyう 14o gyd su Act an kare ElI oct an aud