What are the implications of variation in RNA replication fidelity in organisms with an RNA Genome?
What are the implications of variation in RNA replication fidelity in organisms with an RNA Genome?
The process of DNA replication yields two identical DNA molecules from a single double-stranded molecule. Cellular proof-reading and error-checking mechanisms ensure nearly perfect fidelity of the DNA copies. However, RNA viruses lack replication error-checking mechanisms, and thus have higher rates of genetic variation. Discuss the importance of error-checking mechanisms during replication and how in the absence of these mechanisms genetic variation is introduced.
Previously it was thought that RNA virus replication took place in the solube portion of the cytoplasm of cells. We now know that this is not the case and that the replication complexes are located on specific structures in host cells. Briefly EXPLAIN what structure or structures in the cell are involved and how viruses use them to replicate their RNA genome.
Rabies has a — strand (antisense) RNA for its genome. Describe biosynthesis of this virus including genome replication and protein production.
The process of DNA replication yields two identical DNA molecules from a single double-stranded molecule. Cellular proof-reading and error-checking mechanisms ensure nearly perfect fidelity of the DNA copies. However, RNA viruses lack replication error-checking mechanisms, and thus have higher rates of genetic variation. Discuss the importance of error-checking mechanisms during replication and how in the absence of these mechanisms genetic variation is introduced.
Select all the processes that make the proteome more complex than the genome. RNA editing genome replication peptide bond formation alternative splicing What statement best explains an additional reason for the complexity of the proteome? O Covalent modifications of DNA, such as methylation, increase proteome complexity by altering translation by the ribosome. The ability of ribosomes to translate mRNA in either the 5' to 3' or the 3' to 5' direction increases proteome complexity. The diversity of amino acids increases...
Which of the following statements in NOT true about DNA replication? DNA replication involves synthesis of multiple RNA primers DNA ligase is needed for successful DNA replication DNA replication requires deoxyribonucleotide triphosphates High fidelity of DNA replication is ensured by 5-3' exonuclease activity of DNA polymerase High fidelity of DNA replication is ensured by 3-5' exonuclease activity of DNA polymerases Next
Which of the following statements in NOT true about DNA replication? DNA replication involves synthesis of multiple RNA primers DNA ligase is needed for successful DNA replication DNA replication requires deoxyribonucleotide triphosphates High fidelity of DNA replication is ensured by 5-3 exonuclease activity of DNA polymerase High fidelity of DNA replication is ensured by 3-5' exonuclease activity of DNA polymerases Next
explain how viral genome composition affects its replication cycle? for example dsDNA replicated differently than ss + sense RNA
Discuss Genome characteristics – explain how genome size and gene density differ in simple organisms, such as prokaryotes, versus more complex organisms, such as ourselves. Discuss why these different genome characteristics exist in simple versus complex organisms.
Define termsDNA, RNA, nucleotides, plasmid, helicase, DNA polymerase, primase, RNA primer of DNA replication, mutation, gene, amino acid, polypeptide chain, protein, codon, promoter region of a gene, RNA polymerase, transcription, mRNA, tRNA, RNA, ribosomes, translation, gene expression, conjugation, conjugative pilus, transformation, transductionExplain concept or process• Describe how nucleotides are linked together to form a single strand of nucleic acid• Explain the concept of a complementary pairing • Describe how DNA replication occurs in bacteria • Explain why a primer is necessary for...