Question

Transcriptional control of gene regulation is common in both prokaryotes and eukaryotes. Which of the following is not true? Both prokaryotes and eukaryotes:

A. exhibit both positive and negative control.

B. have repressors that impact expression.

C. often requires interactions with DNA that is not proximal to structural genes.

D. have genes that are closely related in function located proximally on a chromosome

Answer 1

Answer D. have genes that are closely related in function located proximally on a chromosome.

Reason: In both prokaryotes and eukaryotes it is not necessary to have genes with similar functions sitting close together on a chromosome, no such correlation between position and function has been found. All other options are true for both eukaryotes and prokaryotes. (A) Transcriptional control can be both positive (activation) or negative (inhibition). (B) Repressors are present which repress the transcription ultimately impacting gene expression. (C) Transcription often requires interaction with enhancer regions. These enhancer regions are sometimes thousands of base pairs upstream or downstream of the transcription start site. Shadow enhancers are an example of such non proximal enhancers. Thus only option D is not true.

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