Briefly mention the effect a decrease in pH and an increase in lactate concentration have on the triglyceride metabolisation in adipose tissues.
Briefly mention the effect a decrease in pH and an increase in lactate concentration have on the triglyceride metabolisation in adipose tissues.
Homework Answers
Answer-
The pH affects movement of free fatty acids inside and outside of adipocyte. Fatty acids which are not metabolized causes irreversible acidification in adipocyte. Acidification causes flip-flop mechanism by which fatty acids moves across membrane of adipocyte.
Lactic acid suppress lypolysis in adipose tissue by direct activation of GPR81which is antilypolytic activity of insulun. This GPR81 is G-protein coupled receptor for lactate which is expressed in adipose tissue. When high proportion of glucose is utilized by adipose tissue is converted to lactate and this lactic acid shifts lipid metabolism towards carbohydrate metabolism.
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Briefly mention the effect a decrease in pH and an increase in lactate concentration have on the triglyceride metabolisation in adipose tissues.
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