Characterizing a covalent enzyme inhibitor
Tosyl-L-phenylalanine chloromethylketone (TPCK) specifically inhibits chymotrypsin by covalently labeling His57.
a. Propose a mechanism for the inactivation reaction, indicating the structure of the product(s).
b. State why this inhibitor is specific for chymotrypsin.
c. Propose a reagent based on the structure of TPCK that might be an effective inhibitor of trypsin.
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