Deriving an expression for enzymatic rate accelerationBased on the reaction scheme shown b...

Deriving an expression for enzymatic rate acceleration

Based on the reaction scheme shown below, derive an expression for ke/ku, the ratio of the rate constants for the catalyzed and uncatalyzed reactions, respectively, in terms of the free energies of activation for the catalyzed (ΔG‡e) and the uncatalyzed (ΔG‡u) reactions.