Calculation of rate enhancement from energies of activationThe relationships between the f...

Calculation of rate enhancement from energies of activation

The relationships between the free energy terms defined in the solution to Problem 4 above are shown in the following figure:

If the energy of the ES complex is 10 kJ/mol lower than the energy of the E + S, the value of ΔGe’‡ is 20 kJ/mol, and the value of ΔGu‡ is 90 kJ/mol. What is the rate enhancement achieved by an enzyme in this case?