Understanding the implications of transition state stabilization
As noted on page 451, a true transition state can bind to an enzyme active site with a KT as low as 7 x10-26 M. This is a remarkable number, with interesting consequences. Consider a hypothetical solution of an enzyme in equilibrium with a ligand that binds with a KD of 1 x 10-27 M. If theconcentration of free enzyme, [E], is equal to the concentration of the enzyme–ligand complex, [EL], what would [L], the concentration of free ligand, be? Calculate the volume of solution that would hold one molecule of free ligand at this concentration.
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