A study by Bose and colleagues (1998. Blood 92: 3362–3367) and a previous study by Biernaux and others (1996. Bone Marrow Transplant 17: (Suppl. 3) S45–S47) showed that BCR-ABL fusion gene transcripts can be detected in 25 to 30 percent of healthy adults who do not develop chronic myelogenous leukemia (CML). Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.
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