In this chapter, we focused on cancer as a genetic disease, with an emphasis on the relationship between cancer, the cell cycle, and DNA damage, as well as on the multiple steps that lead to cancer. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter,
(a) How do we know that malignant tumors arise from a single cell that contains mutations?
(b) How do we know that cancer development requires more than one mutation?
(c) How do we know that cancer cells contain defects in DNA repair?
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