People with a genetic condition known as Li-Fraumeni syndrome inherit one mutant copy of the p53 gene. These people have a high risk of developing a number of different cancers, such as breast cancer, leukemia, bone cancer, adrenocortical tumors, and brain tumors. Explain how mutations in one cancer-related gene can give rise to such a diverse range of tumors.
HINT: This problem involves an understanding of how tumor-suppressor genes regulate cell growth and behavior. The key to its solution is to consider which cellular functions are regulated by the p53 protein and how the absence ofp53 could affect each of these functions. Also, read about loss of heterozygosity in Section 19.6.
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