Refer to Figure to respond to the following:
(a) Shown here is a hypothetical viral mRNA sequence:
5′-AUGCAUACCUAUGAGACCCUUGGA-3′
Assuming that it could arise from overlapping genes, how many different polypeptide sequences can be produced? What are the sequences?
(b) A base-substitution mutation that altered the sequence in (a) eliminated the synthesis of all but one polypeptide. The altered sequence is shown here:
5′-AUGCAUACCUAUGUGACCCUUGGA-3′
Determine why.
Figure
The coding dictionary. AUG encodes methionine, which initiates most polypeptide chains. All other amino acids except tryptophan, which is encoded only by UGG, are represented by two to six triplets. The triplets UAA, UAG, and UGA are termination signals and do not encode any amino acids.
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