As described in Chapter 12, Ain elements proliferate in the human genome by a process called retrotransposition, in which the Mu DNA sequence is transcribed into RNA, copied into double-stranded DNA, and then inserted back into the genome at a site distant from that of its "parent" Mu gene. Clearly, this has been an extremely efficient process, since Alit genes have proliferated to about 106 copies in the human genome! This efficiency is largely due to the fact that Alt, elements, like many small structural RNAs, carry their promoter sequences within the transcribed region of the gene, rather than 5' to the transcription start site. If Alt, elements carried promoters upstream of the transcription site, as do protein-coding genes, what would happen once they were retrotransposed? Would a retrotransposed Ahi gene be able to proliferate? Explain.
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