The elimination half-life of an antibiotic is 3 hours with an apparent volume of distribution equivalent...
The elimination half-life of an antibiotic is 3 hours with an apparent volume of distribution equivalent to 20% of body weight. The usual therapeutic weight range for this antibiotic is between 5 and 15µg/ml. adverse toxicity for this drug is often observed at serum concentration greater than 20µg/ml. Calculate a dosage regimen (multiple IV doses) that will just maintain the serum drug concentration between 5 and 15µg/ml.
Homework Answers
Let the weight of the patient is X kg.
Vd =20/100* X = 0.2 X L = 200 X ml
Target plasma concentration = 15 micrograms/ ml
Dose = 15 * 200= 3000 X micrograms = 3 X mg
So dose = 3mg/ kg
We have to read readminister the dose when the concentration falls to 5 micrograms/ml.
Half life = 3 hours
K = 0.693/3 = 0.231
A = Ao e^-kt
5 = 15 e^-0.231t
0.231 t = 1.1
t= 1.1/0.231 = 4.7 hours
So the dose should be administered every 4 and half hours.
Add Answer to:
The elimination half-life of an antibiotic is 3 hours with an
apparent volume of distribution equivalent...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Cefotaxime has a volume of distribution of 0.17 L/kg and an elimination half-life of 1.5 hours. What is the peak plasma...
Cefotaxime has a volume of distribution of 0.17 L/kg and an elimination half-life of 1.5 hours. What is the peak plasma drug concentration in a patient weighing 75 kg after receiving 1 g IV of the drug 3 times daily for 3 days?
Drug A has an half-life of 12 hours and a volume of distribution of 80 L....
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L....
Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L. Protocol suggests that atropine is administered as a 1 mg injection and the duration of resuscitation efforts last for 19 minutes. What is the expected concentration, in units of microgram/L, of atropine in the patient's plasma 19 minutes after the single 1 mg dose?
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve...
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve an average steady-state plasmatic concentration of 5 mg/L. The total clearance is normally 5.4 L/h in a 70 Kg-body weight person. Gentamicin is entirely eliminated by glomerular filtration. Your patient, however, is found to have a creatinine clearance one-third of normal. Your initial dosage regimen for this patient would probably be: a. 20 mg every 8 hours b. 33 mg every 8 hours c....
that the infection ave PN 200 Fundamentals of Nursing II harmacology Case Study - Thrombophlebitis-Heparin Tom...
that the infection ave PN 200 Fundamentals of Nursing II harmacology Case Study - Thrombophlebitis-Heparin Tom Moore, a 57 year old man has thrombophlebitis in the right lower leg. units by bolus, was given. Following the IV bolus, Heparin 3000 is, was given. Following the IV bolus. Henarin 50.00 units was given subcutaneously every 6 hours was hours was prescribed. Other therapeutic means to decrease pain and alleviate swelling and redness were also prescribed. An aPTT test was ordered. ebitis...
8/30/2018 Dosage Forms Pharmaceutical calculations Anne Chapter 1 Practice Problems 1. If an insulin injection contains...
8/30/2018 Dosage Forms Pharmaceutical calculations Anne Chapter 1 Practice Problems 1. If an insulin injection contains 100 units originemine, how many milliers should be injected to receive 40 units of insulin 2. An injection contains me of medicati in each militer (ml). If a physician prescribes dose or 0.5 mg to be administered to a hospital patient three times daily, how many of injection will be required over a 5-day period? 3. In a clinical study, a drug produced drowsiness...
1. Oral acetaminophen has been ordered for a young child who has a fever. A liquid...
1. Oral acetaminophen has been ordered for a young child who has a fever. A liquid form has been obtained by the nurse to increase the chance of problem free administration. Prior to administration, the nurse is going through the rights of medication administration. When confirming the right dose, what term is the most appropriate? a. "160 mg" b. "one teaspoon" c. "one third of a tablespoon d. "SmL 2. A pregnant woman asks why she needs to take a...
ame: Date 1. The nurse administers subcutaneous epinephrine to a patient who is experiencing an anaphylactic...
ame: Date 1. The nurse administers subcutaneous epinephrine to a patient who is experiencing an anaphylactic reaction. The nurse should expect to monitor the patient for which symptom? a. Bradycardia b. Tachycardia c. Hypotension d. Hypoglycemia 2. Propranolol (Ideral) is an Adrenergic Blocker used for the treatment of a. Hypertension b. Angina pectoris c. Cardiac Arrhythmias d. All of the above 3. Which part of the Autonomic nervous system helps the body be ready for emergencies? a. parasympathetic b. Adrenal...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve an average steady-state plasmatic concentration of 5 mg/L. The total clearance is normally 5.4 L/h in a 70 Kg-body weight person. Gentamicin is entirely eliminated by glomerular filtration. Your patient, however, is found to have a creatinine clearance one-third of normal. Your initial dosage regimen for this patient would probably be: a. 20 mg every 8 hours b. 33 mg every 8 hours c....
that the infection ave PN 200 Fundamentals of Nursing II harmacology Case Study - Thrombophlebitis-Heparin Tom Moore, a 57 year old man has thrombophlebitis in the right lower leg. units by bolus, was given. Following the IV bolus, Heparin 3000 is, was given. Following the IV bolus. Henarin 50.00 units was given subcutaneously every 6 hours was hours was prescribed. Other therapeutic means to decrease pain and alleviate swelling and redness were also prescribed. An aPTT test was ordered. ebitis...
8/30/2018 Dosage Forms Pharmaceutical calculations Anne Chapter 1 Practice Problems 1. If an insulin injection contains 100 units originemine, how many milliers should be injected to receive 40 units of insulin 2. An injection contains me of medicati in each militer (ml). If a physician prescribes dose or 0.5 mg to be administered to a hospital patient three times daily, how many of injection will be required over a 5-day period? 3. In a clinical study, a drug produced drowsiness...
1. Oral acetaminophen has been ordered for a young child who has a fever. A liquid form has been obtained by the nurse to increase the chance of problem free administration. Prior to administration, the nurse is going through the rights of medication administration. When confirming the right dose, what term is the most appropriate? a. "160 mg" b. "one teaspoon" c. "one third of a tablespoon d. "SmL 2. A pregnant woman asks why she needs to take a...
ame: Date 1. The nurse administers subcutaneous epinephrine to a patient who is experiencing an anaphylactic reaction. The nurse should expect to monitor the patient for which symptom? a. Bradycardia b. Tachycardia c. Hypotension d. Hypoglycemia 2. Propranolol (Ideral) is an Adrenergic Blocker used for the treatment of a. Hypertension b. Angina pectoris c. Cardiac Arrhythmias d. All of the above 3. Which part of the Autonomic nervous system helps the body be ready for emergencies? a. parasympathetic b. Adrenal...
Most questions answered within 3 hours.
-
Calculate the pH of each of the following solutions.
0.50 M HBr
3.1×10−4 M KOH
4.2×10−5...
asked 2 hours ago -
For the year ended December 31, Depot Max’s cost of merchandise
sold was $85,600. Inventory at the...
asked 2 hours ago -
Week 10 - Professional Memo Assignment
Professional Memo Assignment
Your mission for this week, should you...
asked 2 hours ago -
Write a Python program that stores the data for each
player on the team, and it...
asked 2 hours ago -
In
the last 3 months, mike never knows when he is going to get his
allowance...
asked 2 hours ago -
Is Ca(OH)2 a Bronsted base, Lewis base, or both? Why?
asked 2 hours ago -
1A- Why don’t voters complain about U.S. tariffs on imported
sugar?
Because sugar is only a...
asked 2 hours ago -
Cash Payback Period
Primera Banco is evaluating two capital investment proposals for
a drive-up ATM kiosk,...
asked 2 hours ago -
Create a button in Swift (Xcode) that will create a charge,
create a charge using Stripe's...
asked 2 hours ago -
The reaction rate of CO and NO2 in the reaction
CO(g) + NO2(g) → CO2(g) +...
asked 2 hours ago -
Imagine that a chemist puts 6.40 mol each of
C3H8 and O2 in a 1.00-L container...
asked 3 hours ago -
How much money should be invested today in order to have $8340
at the end of...
asked 3 hours ago