Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L....
Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L. Protocol suggests that atropine is administered as a 1 mg injection and the duration of resuscitation efforts last for 19 minutes.
What is the expected concentration, in units of microgram/L, of atropine in the patient's plasma 19 minutes after the single 1 mg dose?
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Atropine has an elimination half-life of 3 hours and a volume of
distribution of 430 L....
You are asked to work with a team of healthcare professionals to review the emergency medications...
You are asked to work with a team of healthcare professionals to review the emergency medications used in a code blue. One medication, atropine, is often administered as a single intravenous bolus dose. While reviewing the pharmacokinetics of atropine, you identify that atropine has an elimination half- life of 2.7 hours and a volume of distribution of 370 L. Your hospital protocols also suggest atropine is administered as a 1 mg intravenous injection and that teh duration of resuscitation efforts...
The drug has a hal-life of 3 hours and a volume of distribution of 100 L....
The drug has a hal-life of 3 hours and a volume of distribution of 100 L. The drug is administered for 12 hours at 300 mg/hr rate. Calculate the plasma concentration (mg/L) 6 hours from the end of the infusion.
Drug A has an half-life of 12 hours and a volume of distribution of 80 L....
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
Cefotaxime has a volume of distribution of 0.17 L/kg and an elimination half-life of 1.5 hours. What is the peak plasma...
Cefotaxime has a volume of distribution of 0.17 L/kg and an elimination half-life of 1.5 hours. What is the peak plasma drug concentration in a patient weighing 75 kg after receiving 1 g IV of the drug 3 times daily for 3 days?
Are these pharmacology questions correct? 16 The volume of distribution of a drug in the body...
Are these pharmacology questions correct?
16 The volume of distribution of a drug in the body is always equal to which of the following? The total volume of the body The volume of extracellular fluid in the body The volume of water in the body The total volume of the body minus the blood volume None of the above (a) (b) (c) (d) (e) volume of distribution are reported to be 3 hours and 0.25 L/kg respectively. Determine the expected...
The elimination half-life of an antibiotic is 3 hours with an apparent volume of distribution equivalent...
The elimination half-life of an antibiotic is 3 hours with an apparent volume of distribution equivalent to 20% of body weight. The usual therapeutic weight range for this antibiotic is between 5 and 15µg/ml. adverse toxicity for this drug is often observed at serum concentration greater than 20µg/ml. Calculate a dosage regimen (multiple IV doses) that will just maintain the serum drug concentration between 5 and 15µg/ml.
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the...
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the infusion rate necessary to mantain a steady state concentration of 12 mg/L in a 50 year old patient. O a 62.4 mg Ob. 520 mg C0.67 mgn O d. 43 mg
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3...
The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3 hours, and volume of distribution 2 L/Kg. A 65 Kg patient requires an infusion in order to attain the plasmatic concentration of 6 mg/L. Recommend a loading dose and constant rate infusion (K0) for this treatment
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
You are asked to work with a team of healthcare professionals to review the emergency medications used in a code blue. One medication, atropine, is often administered as a single intravenous bolus dose. While reviewing the pharmacokinetics of atropine, you identify that atropine has an elimination half- life of 2.7 hours and a volume of distribution of 370 L. Your hospital protocols also suggest atropine is administered as a 1 mg intravenous injection and that teh duration of resuscitation efforts...
The drug has a hal-life of 3 hours and a volume of distribution of 100 L. The drug is administered for 12 hours at 300 mg/hr rate. Calculate the plasma concentration (mg/L) 6 hours from the end of the infusion.
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
Are these pharmacology questions correct?
16 The volume of distribution of a drug in the body is always equal to which of the following? The total volume of the body The volume of extracellular fluid in the body The volume of water in the body The total volume of the body minus the blood volume None of the above (a) (b) (c) (d) (e) volume of distribution are reported to be 3 hours and 0.25 L/kg respectively. Determine the expected...
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the infusion rate necessary to mantain a steady state concentration of 12 mg/L in a 50 year old patient. O a 62.4 mg Ob. 520 mg C0.67 mgn O d. 43 mg
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
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