Homework Answers
Volume of Distribution
16 . The volume of distribution of a drug is the proportionality constant between the amount of drug in the body and the plasma concentration of the drug:
where Vd is the volume of distribution, X is the amount of drug in the body at a particular time, and Cp is the plasma drug concentration at that time. In other words, the volume of distribution is the volume that drug would occupy if it were present throughout the body at the plasma concentration.
If a drug is bound extensively to plasma proteins (i.e., fup is very small), the volume of distribution is approximately equal to the volume of plasma water or about 50 ml/kg of body weight
18. The answer is 12.5%
Half life is 24 hours.
So initially 100%
After 24 hours 50%
Then 24+24 = (48) hrs 25%
After 24+24+24 = (72) hours 12.5% .
17. Calculation for 2nd question and the question both are right.
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16 The volume of distribution of a drug in the body...
1. A new drug was given in a single intravenous dose of 200 mg to an...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
pharmacokinetics problem. please show work. A drug is reported to have substantial drug distribution and bi-phasic...
pharmacokinetics problem. please show work.
A drug is reported to have substantial drug distribution and bi-phasic drug elimination following a single 50 mg intravenous bolus dose to a group of healthy adult patients. You have determined the following variables for this system: Parameter Value 7.5 (mg/L) | 12.0 (mg/L) | 0.7799 (hr) 0.1359 (hr) k10 0.1991 (hr) 0.1844 (hr 1) 0.5322 (hr) What is the volume of the system when a distribution equilibrium has been established? NOTE: Provide your answer...
Pharmacokinetics problem. please show work. A drug is reported to have substantial drug distribution and bi-phasic...
Pharmacokinetics problem. please show work.
A drug is reported to have substantial drug distribution and bi-phasic drug elimination following a single 75 mg intravenous bolus dose to a group of healthy adult patients. You have determined the following variables for this system: Parameter Value 4.3 (mg/L) | 12.7 (mg/L) 10.8024 (hr) 0.3415 (hr) 0.3996 (hr-1) 0.0585 (hr) 0.6858 (hr) kio What is the volume of the central compartment? NOTE: Provide your answer in units of L. Do not include units...
plz, answer all questions clearly and correctly. i am begging you ex of activity? in a...
plz, answer all questions clearly and correctly. i am begging
you
ex of activity? in a single intra exactly, what 3. A new drug was given in a single intravenous dose of 200 mg to an 80-kg adult male patient. After 6 hours, the plasma drug concentration of drug was 1.5 mg/100 mL of plasma. Assum- ing that the apparent V, is 10% of body weight, compute the total amount of drug in the body fluids after 6 hours. What...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L....
Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L. Protocol suggests that atropine is administered as a 1 mg injection and the duration of resuscitation efforts last for 19 minutes. What is the expected concentration, in units of microgram/L, of atropine in the patient's plasma 19 minutes after the single 1 mg dose?
What is the single intravenous bolus dose necessary to produce a plasma drug concentration of 170...
What is the single intravenous bolus dose necessary to produce a plasma drug concentration of 170 nanograms per milliliter one hour after the injection? The answer needs to be in milligrams. A = 1,251.2 nanograms per milliliter B = 786 nanograms per milliliter Alpha = 0.6573 hr-1 Beta = 0.1339 hr-1 The reported central compartment volume of distribution is 7.4 L/kg and the patient weighs 90.1 kilograms.
Drug A has an half-life of 12 hours and a volume of distribution of 80 L....
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
A drug that fully saturates the intestinal transporters required for its absorption necessitates 2.5 hours to be complet...
A drug that fully saturates the intestinal transporters required for its absorption necessitates 2.5 hours to be completely absorbed after administering a 100mg dose orally to a volunteer. Once absorbed, the drug has rapid distribution in the body. A 50 mg dose of the drug administered by IV bolus to the same volunteer (in a separate research session) results in plasma concentrations of 1800 ug/L at time 0 hr and 1150 ug/L at time 3.0 hr. If a patient with...
You are asked to work with a team of healthcare professionals to review the emergency medications...
You are asked to work with a team of healthcare professionals to review the emergency medications used in a code blue. One medication, atropine, is often administered as a single intravenous bolus dose. While reviewing the pharmacokinetics of atropine, you identify that atropine has an elimination half- life of 2.7 hours and a volume of distribution of 370 L. Your hospital protocols also suggest atropine is administered as a 1 mg intravenous injection and that teh duration of resuscitation efforts...
pharmacokinetics problem. please show work.
A drug is reported to have substantial drug distribution and bi-phasic drug elimination following a single 50 mg intravenous bolus dose to a group of healthy adult patients. You have determined the following variables for this system: Parameter Value 7.5 (mg/L) | 12.0 (mg/L) | 0.7799 (hr) 0.1359 (hr) k10 0.1991 (hr) 0.1844 (hr 1) 0.5322 (hr) What is the volume of the system when a distribution equilibrium has been established? NOTE: Provide your answer...
Pharmacokinetics problem. please show work.
A drug is reported to have substantial drug distribution and bi-phasic drug elimination following a single 75 mg intravenous bolus dose to a group of healthy adult patients. You have determined the following variables for this system: Parameter Value 4.3 (mg/L) | 12.7 (mg/L) 10.8024 (hr) 0.3415 (hr) 0.3996 (hr-1) 0.0585 (hr) 0.6858 (hr) kio What is the volume of the central compartment? NOTE: Provide your answer in units of L. Do not include units...
plz, answer all questions clearly and correctly. i am begging
you
ex of activity? in a single intra exactly, what 3. A new drug was given in a single intravenous dose of 200 mg to an 80-kg adult male patient. After 6 hours, the plasma drug concentration of drug was 1.5 mg/100 mL of plasma. Assum- ing that the apparent V, is 10% of body weight, compute the total amount of drug in the body fluids after 6 hours. What...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
You are asked to work with a team of healthcare professionals to review the emergency medications used in a code blue. One medication, atropine, is often administered as a single intravenous bolus dose. While reviewing the pharmacokinetics of atropine, you identify that atropine has an elimination half- life of 2.7 hours and a volume of distribution of 370 L. Your hospital protocols also suggest atropine is administered as a 1 mg intravenous injection and that teh duration of resuscitation efforts...
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