Question

how is caffine metabolized

Answer 1

ans-***starting with the first step of caffeine degradation, for the metabolic pathways concerning Theophylline and ******theobromine,paraxanthine, which is the main metabolite of caffeine and has powerful biological effects. The numbers indicate the percentages of metabolites obtained after caffeine metabolism. AAMU, 5-Acetylamino-6-amino-3-methyluracil; AFMU, 5-acetylamino-6-formylamino-3-methyluracil; CYP, Cytochrome P450 followed by the number corresponding to each specific isoform; NAT2, N-acetyltransferase-2; XO, xanthine oxidase.Finally, xanthine oxidase (XO) catalyzes the conversion of 1-methylxantine (1MX) to 1-methyluric acid (1MU).    ****The ratios used to measure xanthine oxidase activity follow a normal distributed [*********** How the body metabolises caffeineCaffeine is primarily metabolised in the liver by cytochrome P450 enzymes, which are responsible for more than 90% of caffeine clearance. The enzyme responsible for metabolism of caffeine is coded for by the gene CYP1A2. ****The large variability of CYP1A2 activity influences the clearance of caffeine and may be affected by factors such as gender, race, genetic polymorphisms, disease, and exposure to inducers. Two studies have reported that regular intakes of caffeine for one week did not alter caffeine Pharmacokinetics. However, a further study suggested that the daily consumption of at least 3 cups of coffee increased CYP1A2 activity] THANK YOU VERY MUCH