Question

Acute inflammation involves a variety of cell types including most cells, endothelial cells, neutrophills, macrophages, and fibroblasts. communication and coordination among these cells is affected by ?

Answer 1

Inflammation refers to the physical condition in which a part of the body turns becomes hot, red, and swollen. Pain is experienced in this part of inflammation. It occurs in response to an infection or an injury. The cells involved in acute or severe inflammation are neutrophils, mast cell, fibroblasts, macrophages, and endothelial cells.

These cells use cytokines and chemokines for the communication and coordination among each other. Cytokines come in the category of signalling molecules that helps in communication in case of inflammation. These the peptides, proteins, or glycoproteins that are secreted by the infected cells. These signal molecules are named based on the cell that secretes them such as lymphokines are secreted by lymphocytes. There is a very high affinity between the cytokines and their receptor.

These signalling molecules affect the control and coordination and hence, the abnormality in the expression of these molecules can lead to the abnormal immune response in inflammation or any other infection. The malfunctioning can also occur due to any pathogenic infection that mimics and misleads the signalling of immune cells.