In the formation of the thioester in the oxidation of Glyceraldehyde-3-phosphate by Glyceraldehyde-3-dehydrogenase which of the...
In the formation of the thioester in the oxidation of
Glyceraldehyde-3-phosphate by Glyceraldehyde-3-dehydrogenase which
of the following statements is true?
A) The thioester intermediate is more stable (lower free energy)
than the reactant
B) the thioester intermediate is less stable (higher free energy)
than the reactant
C) the thioester intermediate is more stable (lower free energy)
than the product
D) In the organic chemistry lab, thioester allows for the formation
of acyl-phosphate
E) in the organic chemistry lab, thoiester formation allows for the
oxidation of the aldehyde to a carboxylic acid
I think the answer is either A, or C. May someone please explain? Thank you!!
Homework Answers
Solution:
The correct option is A.
The thioester intermediate has lower free energy than reactant, therefore posses higher stability than reactant.
Glyceraldehyde-3-phosphate is a high energy containing phosphate, thus form a more stable thioester intermediate which bears less free energy.
Add Answer to:
In the formation of the thioester in the oxidation of
Glyceraldehyde-3-phosphate by Glyceraldehyde-3-dehydrogenase which
of the...
The mechanism of glyceraldehyde 3 phosphate dehydrogenase. In step 1 (Top Left) the sulfur from the cysteine loses its...
The mechanism of glyceraldehyde 3 phosphate dehydrogenase. In
step 1 (Top Left) the sulfur from the cysteine loses its hydrogen
to the carbonyl carbon of the substrate. I think is wrong and the
hydrogen is stolen by the histidine (nitrogen) using a base
catalyst reaction.
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The mechanism of glyceraldehyde 3 phosphate dehydrogenase. In
step 1 (Top Left) the sulfur from the cysteine loses its hydrogen
to the carbonyl carbon of the substrate. I think is wrong and the
hydrogen is stolen by the histidine (nitrogen) using a base
catalyst reaction.
lser Glyceraldehyde 3-phosphate NAD CONH2 H -N + HH Hemithioacetal Oxidation NAD NADH CONH CONH2 Но RN + H -N / H Η Η Hн s NADH NAD Thioester intermediate Thioester intermediate Phosphorylation CONH2 O...
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