answer :-
if the plasma protein binding of cyclosporine increases, the volume of distribution of cyclosporine:
answer :- decreases
explanation:- if plasma protein binding increases, volume of distribution decreases
If the plasma protein binding of the drug cyclosporine increases, the volume of distribution of cyclosporine:...
Warfarin readily binds to plasma proteins such as albumin. Your colleague insists that this plasma protein binding allows warfarin to travel around the body better and helps to increase the distribution of the drug. Explain why your colleague is wrong in one sentence.
Drug A is a High extraction ratio drug and it is mostly eliminated by hepatic metabolism. When drug A is administered to a patient with a decreased protein binding for drug A, the hepatic clerance of Drug A will: increase cannot tell decrease show little change
If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5 ug/mL, calculate the apparent volume of distribution. The correct answer is 40 L. Please show how this question is solved.
How plasma protein binding can influence biodistribution and activity of antisense oligonucleotides and plasmid DNA?
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
A drug D binds to a protein P with binding constant K1 = 1.58x10^6 at temperature T1 = 298 K and with binding constant K2 = 1x10^6 at temperature T1 = 330 K. Determine how the extent of the binding of the drug θ changes if the analytical concentration of the drug [D]0 = 50 pM is held constant as the temperature is raised from 273 K to 373 K. You can assume that the temperature dependence of the binding...
volume of distribution for a drug is 16L/kg. what is the required dose/prescription if the desired plasma concentration is 50 ug/L?
Total plasma volume is important in determining the required plasma component in blood replacement therapy for a person undergoing surgery. Plasma volume is influenced by the overall health and physical activity of an individual. Suppose that a random sample of 46 male firefighters are tested and that they have a plasma volume sample mean of x = 37.5 ml/kg (milliliters plasma per kilogram body weight). Assume that σ = 7.20 ml/kg for the distribution of blood plasma. We were unable...
Steroid hormones exert their action by: a. crossing the plasma membrane and binding to nuclear receptors initiating or altering the expression of a gene b. binding to receptors located on the plasma membrane and initiating a secondary messenger effect active transport across the plasma membrane and attaching to cytoplasmic protein receptors d. crossing the plasma membrane and binding to cytoplasmic receptors Hypoglycemia is defined as a blood sugar: a. Less than 7.8 mmol/L b. Less than 2.5 mmol/L c. Greater...
The drug has a hal-life of 3 hours and a volume of distribution of 100 L. The drug is administered for 12 hours at 300 mg/hr rate. Calculate the plasma concentration (mg/L) 6 hours from the end of the infusion.