volume of distribution for a drug is 16L/kg. what is the required dose/prescription if the desired...

Question

Question

volume of distribution for a drug is 16L/kg. what is the required dose/prescription if the desired plasma concentration is 50 ug/L?

Answer 1

Answer #1

Volume of distribution of a drug - 16L/kg

Plasma concentration - 50ug/L = 0.05 mg/L

Volume of Distribution (L) = Amount of drug in the body (mg) / Plasma concentration of drug (mg/L)

16L = required dose / 0.05mg/L

Required dose = 16× 0.05

= 0.8mg /kg

Answer 2

Similar Homework Help Questions

A drug that fully saturates the intestinal transporters required for its absorption necessitates 2.5 hours to be complet...

A drug that fully saturates the intestinal transporters required for its absorption necessitates 2.5 hours to be completely absorbed after administering a 100mg dose orally to a volunteer. Once absorbed, the drug has rapid distribution in the body. A 50 mg dose of the drug administered by IV bolus to the same volunteer (in a separate research session) results in plasma concentrations of 1800 ug/L at time 0 hr and 1150 ug/L at time 3.0 hr. If a patient with...
Are these pharmacology questions correct? 16 The volume of distribution of a drug in the body...

Are these pharmacology questions correct? 16 The volume of distribution of a drug in the body is always equal to which of the following? The total volume of the body The volume of extracellular fluid in the body The volume of water in the body The total volume of the body minus the blood volume None of the above (a) (b) (c) (d) (e) volume of distribution are reported to be 3 hours and 0.25 L/kg respectively. Determine the expected...
Drug A has an half-life of 12 hours and a volume of distribution of 80 L....

Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?

Vancomycin is an antibiotic with volume of distribution of 0.65L/kg (this is an unusual presentation of...

Vancomycin is an antibiotic with volume of distribution of 0.65L/kg (this is an unusual presentation of the volume of distribution). If the target plasma concentration is 20mg/L was this the appropriate loading dose for the 70kg patient? Why would you want to use a loading dose?
What is the single intravenous bolus dose necessary to produce a plasma drug concentration of 170...

What is the single intravenous bolus dose necessary to produce a plasma drug concentration of 170 nanograms per milliliter one hour after the injection? The answer needs to be in milligrams. A = 1,251.2 nanograms per milliliter B = 786 nanograms per milliliter Alpha = 0.6573 hr-1 Beta = 0.1339 hr-1 The reported central compartment volume of distribution is 7.4 L/kg and the patient weighs 90.1 kilograms.
You want to achieve a particular plasma concentration of a drug of approximately 81 mg/L in...

You want to achieve a particular plasma concentration of a drug of approximately 81 mg/L in a 70 kg adult male. You know that the total volume of distribution for this drug is ~9L. What dose of drug should you give? (Choose the closest approximate value.) 5670 mg 729 mg correct 10 mg 9 mg In order to achieve the same plasma concentration of the above drug in an adult male who is obese (weighing 125 kg) but otherwise healthy,...

Cefotaxime has a volume of distribution of 0.17 L/kg and an elimination half-life of 1.5 hours. What is the peak plasma...

Cefotaxime has a volume of distribution of 0.17 L/kg and an elimination half-life of 1.5 hours. What is the peak plasma drug concentration in a patient weighing 75 kg after receiving 1 g IV of the drug 3 times daily for 3 days?
1. A new drug was given in a single intravenous dose of 200 mg to an...

1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5...

If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5 ug/mL, calculate the apparent volume of distribution. The correct answer is 40 L. Please show how this question is solved.

A 187 lb patient is given a drug with a 1.9 L/kg volume of distribution. What...

A 187 lb patient is given a drug with a 1.9 L/kg volume of distribution. What is the actual volume of distribution of this drug in this specific patient? (NOTE: Provide your answer in units of L)