Half life refers to the concentration of a drug reduced exactly half to the actual strength.
Here the drug has a half life of 12 hours ,it means at 12th hour the dose of the drug will be only 50% of the initial dose.
When the first dose is given at 8am (10mg) by 8 pm it will be reaching its half life ,so the concentration will be 5mg.Again when the 8pm(10mg) dose is administered ,the total drug will be 15mg by 8pm
So in the midnight (usually after 6 hours ) approximately by 2 am the amount of drug in patient body will be 7.5mg (15÷2)
16. Suppose that the allergy drug, Sneezebgone, has a half life of 12 hours and is...
A certain drug is eliminated from the bloodstream exponentially with a half-life of 24 hours. Suppose that a patient receives an initial dose of 15 milligrams of the drug at midnight. a) How much of the drug is in the patient's blood at noon the next day? b) Estimate when the drug concentration will reach 20% of its initial level.
If the half-life for decomposition of a drug is 12 hours, how long (in hours) would it take for 500 mg of the drug to decompose by 10%? Assuming first order kinetics and at a constant temperature: (Assume must be numeric; round the final answer to the nearest WHOLE number)
Drug A has an half-life of 12 hours and a volume of distribution of 80 L. How many mg of drug are in the body when the plasma concentration is 0.4 ug/mL?
The patient is taking a 2-mg dose of ropinerol XR. The drug has a half-life of 12 hours. How long will it be before only 0.25 mg of this drug remains in the patient's system?
Atropine has an elimination half-life of 3 hours and a volume of distribution of 430 L. Protocol suggests that atropine is administered as a 1 mg injection and the duration of resuscitation efforts last for 19 minutes. What is the expected concentration, in units of microgram/L, of atropine in the patient's plasma 19 minutes after the single 1 mg dose?
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the infusion rate necessary to mantain a steady state concentration of 12 mg/L in a 50 year old patient. O a 62.4 mg Ob. 520 mg C0.67 mgn O d. 43 mg
Caffeine has a therapeutic index of approximately 100:1. If the ED50 for caffeine is 12 mg/kg, what is the LD50? In a typical dose-response curve graph, what is placed along the vertical, y-axis? Sheila weighs 55 kg (121 pounds). She starts her day off with a large cup of Starbucks coffee (330 mg caffeine). Every day she drinks at least three large cans of Monster energy drink, each containing 160 mg of caffeine. In the evening, she drinks two cups...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His residual creatinine clearance is <5mL/min. The patient is given tobramycin, an aminoglycoside antibiotic, at a dose, at a dose of 1 mg/kg by IV bolus injection. Tobramycin is 90% excreted unchanged in the urine, is less than 10% to plasma protein, and has elimination half-life 2.2 hours in patient with normal renal function. In this patient, tobramycin has an elimination t1/2 of 50hours during...
Drug A has a Clearance of S.6 /hr and a half-life of 12 hours. Calculate the volume of distribution in Liters (round to the nearest integer number)
The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3 hours, and volume of distribution 2 L/Kg. A 65 Kg patient requires an infusion in order to attain the plasmatic concentration of 6 mg/L. Recommend a loading dose and constant rate infusion (K0) for this treatment