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Drug A has a Clearance of S.6 /hr and a half-life of 12 hours. Calculate the volume of distribution in Liters (round to the n
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Answer #1

volume of distribution is the theoretical volume that would be necessary to contain the total would be necessary to contain the total amount at same contraction..

clearance. 5.6L/ hr

vod= CL/ KE

t1/2 = .693/ KE

so. KE = .693 / t1/2

KE= .693/ 12

KE = 0.057

VOD. = CL /KE

VOD = 5.6/ .057

VOD = 98.2

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