Question

A drug has linear pharmacokinetics, an half-life of 6 hours and a volume of distribution of 43L. How long it will take to reach 90% of steady state in a 33 year old patient receiving a 20mg/hr V-infusion? a. 20 hours b. 36 hours Oc. 142 hours Odinot enough information provided

Answer 1

Answer:a 20 hours

the drug is a linear pharmakokinetic drug which says that the dose of drug does not have any impact of the drug concentration in the body , The half life of the drug is 6 hrs which shows that 50% of the drug concentartion in the body is reduced after 6 hours .A steady state is a state in which the pharmacokinetics of a drug has reached its equilibrium with  its eliminated and generaly a staeady state is 4-5 times of the half life so as per the question a 90 % steady state is reached at 20 hours because 4*6 is 24 which is 100* and 90 * is nearing 20 hours