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Can you please help me develop a clinical research question related to central line-associated bloodstream infections...

Can you please help me develop a clinical research question related to central line-associated bloodstream infections using the PICOT (patient population, intervention, comparison group, outcome of interest, timeframe)?

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* PICOT question related to central line associated blood stream infection.

       * A group of patients admitted in the ICU (P) how effective is using combination

         of chlorohexidine and silver sulfadiazine during skin preparation for central line

         insertion (I) compared to chlorohexidine alone (C) to prevent central line associated

         blood stream infection (O) during the treatment period (T) ?

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