Question

1. Inflammation can play a role in cancer (development and/or progression) in which of the following ways? Select all that apply. Question options:

A) TILs can secrete pro-inflammatory cytokines that promote cancer.

B) TAMs can attack cancer cells and destroy them.

C) Ulcerative colitis can progress to colon cancer.

D) Immune cells associated with a cancer can secrete angiogenic and growth factors.

E) Hepatitis C infection can lead to liver cancer.

F) Hypercholesterolemia can develop into leukemia.

2. Tumor suppressor genes have all of the following characteristics. Choose all that apply. Question options:

A) Tumor suppressor genes often have loss-of-function mutations in cancer cells.

B) Some viral infections can inactivate tumor suppressor genes.

C) Tumor suppressor genes are most active in the nucleus.

D) Mutations in tumor suppressor genes are found in the vast majority of tumors.

E) Tumor suppressor genes include TP-53, BRCA 1 and BRCA 2, Von Hippel-Lindau and RAS.

F) Tumor suppressor genes are frequently over expressed in cancer cells.

G) Tumor suppressor genes must have mutations or deletions of both copies (alleles) in order for a cell to become cancerous.

Answer 1

Question 1 answer A,B,C and D are right and E and F are wrong.

Question 2 answer A and F are wrong . All others are the chatesteristic of tumor suppressor Gene.