Hyperhomocysteinemia is a disorder of the methionine metabolism that leads to the accumulation of homocysteine and...
Hyperhomocysteinemia is a disorder of the methionine metabolism that leads to the accumulation of homocysteine and its metabolites. Research has shown that this disease can lead to gastrointestinal disorders, cardiovascular disease, autoimmune diseases, and Alzheimer’s. Describe two pathways that can reduce homocysteine levels to include cofactors and enzymes.
Homework Answers
ANSWER:-
1. Cystathionine β-synthase catalyses the condensation of homocysteine and serine to give cystathionine. This reaction uses pyridoxine (vitamin B6) as a cofactor. Cystathionine γ-lyase then converts this double amino acid to cysteine, ammonia, and α-ketobutyrate.
2. Homocysteine can be recycled into methionine. This process uses N5-methyl tetrahydrofolate as the methyl donor and cobalamin (vitamin B12)-related enzymes.
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Hyperhomocysteinemia is a disorder of the methionine metabolism
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