The synthesis of protein or polypeptides from individual amino acids would seem to cause a decrease...

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The synthesis of protein or polypeptides from individual amino acids would seem to cause a decrease...

The synthesis of protein or polypeptides from individual amino acids would seem to cause a decrease in entropy and require some sort of energy input. How is the energy supplied for protein synthesis?

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Answer 1

Answer #1

ATP and GTP molecules provide the energy for protein synthesis.

During initiation phase we have 2 ATP + 1 GTP

mRNA activation needs 1 ATP (ATP---> ADP + P).

1 ATP is used (ATP---> ADP + P).for formation of 48s initiation complex

GTP bound to eIF2 will be hydrolized---> GDP-eIF2 + P. This reaction causes the release of eIF3 & eIF1A from 48s init. complex ---> rapid association of 60s with 40s & thus forming 80s initiation complex.

For elongation: 2 GTP

For termination: 1 GTP

Overall in each translation cycle: 2 ATP + 4 GTP & 1 ATP in AA activation.

For a protein composed of "n" number of amino acids, it takes (4n)-1 number of ATP for the translation process.

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Answer 2

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