Question

A gene is coded by a transcript that is 1200 nucleotides long.

What would be the effect on the protein encoded by this gene, of a single nucleotide addition at position 100, position 600 or position 1150? And what would happen if that addition was inside an intron?

Answer 1

Insertion at 100th position,

99 bases will encode for normal 33 amino acids and after that all the amino acids will be changed.

Till 600 bases, 200 amino acids will be there. An insertion at 600th position, will change amino acid from 200 position onwards.

Till 1149 bases, 383 amino acids will be formed. Amino acids will change from 384 onwards.

If addition occurs in introns, than there will be no effect on the sequence of amino acid because introns are removed before translation.

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