provide a reason for the changed VEGF expression, and explain your reasoning.
Homework Answers
For the increase in the expression of the VEGF which is vascular epithelial growth factor and helpful in the angiogenesis in the cancer cells in the higher amount depends on the expression of the HIF1a that is the hypoxia indicuble factor 1 alpha that is helpful in the expression dynamics of the VEGF. It has been seen that the binding of the prolin in the hypoxia condition to HIF1a can lead to the rapid degradation of the HIF1a and ultimately reduces down the expression for VEGF as well.
Thus it is important that the affinity of the proline towards the HIF1a has to change thus, the conversion of the proline to alanine will change the overall affinity of the ligand towards the macromolecule and thus lead to the increase in the HIF1a expression as well that will lead to the increase in the VEGF gene expression too.
Add Answer to:
provide a reason for the changed VEGF expression, and explain
your reasoning.
Question 36 6 pts...
Question 36 6 p A mutation that changes the prollnes normally hydroxylated In HIF1a to alanines...
Question 36 6 p A mutation that changes the prollnes normally hydroxylated In HIF1a to alanines dramatically increases VEGF expression in the absence of hypoxia. Provide a likely reason for this changed VEGF expression, and explain your reasoning.
please answer all 6 questions Question 27 3 pts TRBP is a protein important for the...
please answer all 6 questions
Question 27 3 pts TRBP is a protein important for the formation of the RISC complex. Which of the following would you expect in cells with null mutations in TRBP? o Reduced siRNA-mediated mRNA degradation o Increased miRNA-mediated translational repression o Increased deadenylase-mediated mRNA degradation o Reduced proteasome-mediated protein degradation D Question 28 3 pts A protein that binds to the 3' UTR of a VEGF mRNA and promotes deadenylation and uncapping is likely to:...
6. Which of the following mutations would most likely have the severest consequences: Explain your reasoning....
6. Which of the following mutations would most likely have the severest consequences: Explain your reasoning. a. A change in amino acid recognition of an aminoacyl-tRNA synthetase b. A frame shift mutation at the end of the coding sequence of a gene A mutation at a splice junction C.
Please answer and explain reasoning and methodology to achieve the answer. 3. (6 pts) Provide the...
Please answer and explain reasoning and
methodology to achieve the answer.
3. (6 pts) Provide the required starting materials for the synthesis of the desired product shown using a Suzuki coupling. You do NOT need to give the catalyst, solvent or reaction conditions. Suzuki coupling Oph Meo2c1 desired product
Question 8 2 pts Which of these has the higher boiling point, Hor)? Explain your reasoning...
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would occur during a viral infection. (8 pts) gh 8, with 1 being the first and...
would occur during a viral infection. (8 pts) gh 8, with 1 being the first and 8 being the last) as they IFNAR1/2 is bound by ligand NK cell identifies the cell as healthy and does not kill it Type I interferon-stimulated genes are induced Type 1 Interferons all are secreted by virally-infected cells I protein expression on the plasma membrane becomes elevated STAT proteins are phosphorylated NK cell inhibitory receptor-mediated signaling increases JAK and Tyk2 are activated 3. Briefly...
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Question 23 1 pts A B 6V switch open w Figure 6 What is the potential...
Question 23 1 pts A B 6V switch open w Figure 6 What is the potential difference in volts across Rp in Fig. 6? Question 24 1 pts Indicate your reasoning for your answer to problem 23. Question 30 1 pts A B + 6V switch M closed F Figure 7 To one d.p., what is the current in amps flowing through the battery in Fig. 7? Question 31 1 pts Indicate your reasoning for your answer to problem 30....
Question 36 6 p A mutation that changes the prollnes normally hydroxylated In HIF1a to alanines dramatically increases VEGF expression in the absence of hypoxia. Provide a likely reason for this changed VEGF expression, and explain your reasoning.
please answer all 6 questions
Question 27 3 pts TRBP is a protein important for the formation of the RISC complex. Which of the following would you expect in cells with null mutations in TRBP? o Reduced siRNA-mediated mRNA degradation o Increased miRNA-mediated translational repression o Increased deadenylase-mediated mRNA degradation o Reduced proteasome-mediated protein degradation D Question 28 3 pts A protein that binds to the 3' UTR of a VEGF mRNA and promotes deadenylation and uncapping is likely to:...
6. Which of the following mutations would most likely have the severest consequences: Explain your reasoning. a. A change in amino acid recognition of an aminoacyl-tRNA synthetase b. A frame shift mutation at the end of the coding sequence of a gene A mutation at a splice junction C.
Please answer and explain reasoning and
methodology to achieve the answer.
3. (6 pts) Provide the required starting materials for the synthesis of the desired product shown using a Suzuki coupling. You do NOT need to give the catalyst, solvent or reaction conditions. Suzuki coupling Oph Meo2c1 desired product
Question 8 2 pts Which of these has the higher boiling point, Hor)? Explain your reasoning lyke HTML Editore BIVAAIEE11xx, E DO N O T T12pt Paragraph
Question 36 1 pts What is the reasoning behind role modeling? O A manager should select subordinates who are similar to him or her. Having managers act out the role of the subordinate gives them a better understanding of the subordinate's feelings. Having subordinates act out the role of manager in contrived settings gives them a better understanding of directives. O A leader is more likely to build referent power if he or she is sensitive to others' needs and...
Question 25 1 pts A reason that we need to provide a new flu vaccine every year is: All other answers are correct O Spontaneous mutation of virus causing old vaccines to be ineffective Antigenic drift causing old vaccines to be ineffective Antigenic shift causing old vaccines to be ineffective Question 26 1 pts The apparent variety in symptoms and severity of COVID19 cases might be attributable to which factor? The virus targets a cell surface protein found in many...
would occur during a viral infection. (8 pts) gh 8, with 1 being the first and 8 being the last) as they IFNAR1/2 is bound by ligand NK cell identifies the cell as healthy and does not kill it Type I interferon-stimulated genes are induced Type 1 Interferons all are secreted by virally-infected cells I protein expression on the plasma membrane becomes elevated STAT proteins are phosphorylated NK cell inhibitory receptor-mediated signaling increases JAK and Tyk2 are activated 3. Briefly...
Question 23 1 pts A B 6V switch open w Figure 6 What is the potential difference in volts across Rp in Fig. 6? Question 24 1 pts Indicate your reasoning for your answer to problem 23. Question 30 1 pts A B + 6V switch M closed F Figure 7 To one d.p., what is the current in amps flowing through the battery in Fig. 7? Question 31 1 pts Indicate your reasoning for your answer to problem 30....
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