Question

Which of these statements regarding cancer are FALSE? Choose all that apply. Within an individual, all metastases from the same primary tumor will have exactly the same mutations Cancer is a genetic disease, which is why the majority of cancers can be linked to mutations inherited from the patients' parents. The defining difference between tumor suppressors and proto-oncogenes is that they are associated with different types of pathways. Individuals with familial adenomatous polypsis can develop hundreds of polyps, but not all of these polyps progress and develop into colon cancer.

Answer 1

Answer- Cancer is the genetic disease ,which is why the majority of the cancers can be linked to mutations inherited from parents.

Within an individual,all metastases from the same primary tumor will have exactly the same mutation.

Individuals with familial adenomatous polypsis can develop hundreds of polyps,but not all of these polyps progress and develop into colon cancer.

Cancer can develop due to mutation in the inherited tumor suppressor genes that is only 5-10 % but majority of the cancer occurs due to the acquired gene mutation during lifetime. The all metastases from the same primary tumor will not have exactly the same mutation , as it metastasizes it becomes more invasive than primary tumor because of gain or loss function mutation in oncogenes. The most The The proto-oncogene is involved in the positive cell cycle, over expression of proto-oncogenes results into growth of oncogenic cells whereas tumor suppressors genes are involved in the negative cell cycle, the over expression of the tumor suppressors genes inhibits the growth of the oncogenic cells.The familial adenomatous polypsis is the autosomal dominant condition, can developed large number of the polyps and all polyps grow into colon cancer.