Question

In a meta-analysis, what values do luse to compare findings across multiple studies?

Answer 1

The majority of meta-analyses are based on a series of studies to produce a point estimate of an effect and measures of the precision of that estimate. However, methods have been developed for the meta-analyses to be conducted on data obtained from original trials. This approach may be considered the "gold standard" in metaanalysis because it offers advantages over analyses using aggregated data, including a greater ability to validate the quality of data and to conduct appropriate statistical analysis. Further, it is easier to explore differences in effect across subgroups within the study population than with aggregated data. The use of standardized individual-level information may help to avoid the problems encountered in meta-analyses of prognostic factors. It is the best way to obtain a more global picture of the natural history and predictors of risk for major outcomes, such as in scleroderma.This approach relies on cooperation between researchers who conducted the relevant studies. Researchers who are aware of the potential to contribute or conduct these studies will provide and obtain additional benefits by careful maintenance of original databases and making these available for future studies.