Homework Answers
Ans:
Demethylation
Methylation (in case of dimethylation at lysine 9 and 27 on H3 inactive transcription)
Explanation: Histone methylation and demethylation are the mechanism by which methyl groups are added or removed from the histone by the enzymes histone methyl transferase (HMT) and histone demethylase. Methylation and demethylation activate or inactivate transcription depending on which amino acids are methylated or demethylated. Histone methylation in some lysine residues (lysine residues in 9th and 27 position) act as signal for transcription inactivation whereas histone methylation in lysine 4 in histone 3 and and arginine residues in on H3 and H4 activates transcription. Acetylation and phosphorylation are mechanisms by which acetyl and phosphate group are added into the histone by the enzyme histone acetyl transferases (HATs) and kinase and promote transcription activation.
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Which of the following histone modifications generally PREVENTS transcription from occurring? Methylation o acetylation Demethylation Phosphorylation
Compare the mechanisms by which acetylation and methylation of histone lysines affect transcription. Be sure to...
Compare the mechanisms by which acetylation and methylation of histone lysines affect transcription. Be sure to discuss how these modifications impact the charge of the lysine and the association of other proteins.
2. Compare the mechanisms by which acetylation and methylation of histone lysines affect transcription. Be sure...
2. Compare the mechanisms by which acetylation and methylation of histone lysines affect transcription. Be sure to discuss how these modifications impact the charge of the lysine and the association of other proteins.
Which of the following accurately matches a histone tail modification with its effect on transcription? Group...
Which of the following accurately matches a histone tail modification with its effect on transcription? Group of answer choices a Methylation of lysine 4 on the H3 tail activates transcription of downstream genes b Methylation of lysine 4 on the H3 tail activates transcription of upstream genes c Acetylation of lysine 16 on H4 prevents transcription from taking place by blocking RNA polymerase from binding d Acetylation of lysine 16 on H4 prevents transcription from taking place by preventing nucleosome...
Which of the following chemical modifications leads to condensation of chromatin and therefore reduces levels of...
Which of the following chemical modifications leads to condensation of chromatin and therefore reduces levels of transcription? View Available Hint(s) histone methylation, DNA methylation, and histone acetylation histone methylation DNA methylation histone acetylation histone methylation and DNA methylation
9) Which posttranslational modification does not occur on histone tails? (a) Phosphorylation (b) Germination (c) Acetylation...
9) Which posttranslational modification does not occur on histone tails? (a) Phosphorylation (b) Germination (c) Acetylation (d) Methylation
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to...
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to either transcriptional activation or repression. How do you suppose that the same modification - methylation - can mediate different biological outcomes? Explain what is meant when we say two DNA sequences are 'highly conserved'. Why are some sequences conserved and others aren't? In your own words, explain what is meant by "position effect". What is the molecular basis of this phenomenon?
ton is not an energy dependent process in (B)) Falls eukaryotes 43. Histone methylation is associated...
ton is not an energy dependent process in (B)) Falls eukaryotes 43. Histone methylation is associated with Falls gene activation gene silencing Following histones are required during transcription (A) H2A and 2B (B) H3 (C) H4 (D) All of the above (E) H2AZ (c) induction (D) All of the above (E) None of the above 35. 4. DNA methylation silences gene expression AD True (B) Fall Leucine residues in lucine zipper proteins provides h ydrophobic interaction for dimerization (A) True...
Which statements about the modification of chromatin structure in eukaryotes are true? 2 pts a. Acetylation...
Which statements about the modification of chromatin structure in eukaryotes are true? 2 pts a. Acetylation of histone tails in chromatin allows access to DNA for transcription. b. Histone proteins are always permanently placed along a DNA sequence but the binding to DNA can be loosened. c. Methylation of DNA is associated with the gene activation. d. Acetylation of histone tails is a reversible process. e. Some forms of chromatin modification can be passed on to future generations of cells.
Which of the following hypothesizes that the physical and functional status of a certain region of genomic chromatin is dependent upon the patterns of specific histone posttranslational modifications...
Which of the following hypothesizes that the physical and functional status of a certain region of genomic chromatin is dependent upon the patterns of specific histone posttranslational modifications and/or DNA methylation status? a. PTM hypothesis b. Nuclear body hypothesis c. Epigenetic code d. Genetic code
Which of the following statements about chromatin remodeling is incorrect? Select one: O a. Chromatin remodeling...
Which of the following statements about chromatin remodeling is incorrect? Select one: O a. Chromatin remodeling provides the transcription machinery with dynamic access to an otherwise tightly packaged genome. O b. Chromatin remodeling often involves histone modifications (e.g., methylation). O c. Eukaryotes use chromatin remodeling as a mechanism for epigenetic modifications. O d. Prokaryotes use chromatin remodeling to regulate operon activity. O e. Chromatin remodeling plays a central role in the regulation of gene expression.
2. Compare the mechanisms by which acetylation and methylation of histone lysines affect transcription. Be sure to discuss how these modifications impact the charge of the lysine and the association of other proteins.
Which of the following chemical modifications leads to condensation of chromatin and therefore reduces levels of transcription? View Available Hint(s) histone methylation, DNA methylation, and histone acetylation histone methylation DNA methylation histone acetylation histone methylation and DNA methylation
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to either transcriptional activation or repression. How do you suppose that the same modification - methylation - can mediate different biological outcomes? Explain what is meant when we say two DNA sequences are 'highly conserved'. Why are some sequences conserved and others aren't? In your own words, explain what is meant by "position effect". What is the molecular basis of this phenomenon?
ton is not an energy dependent process in (B)) Falls eukaryotes 43. Histone methylation is associated with Falls gene activation gene silencing Following histones are required during transcription (A) H2A and 2B (B) H3 (C) H4 (D) All of the above (E) H2AZ (c) induction (D) All of the above (E) None of the above 35. 4. DNA methylation silences gene expression AD True (B) Fall Leucine residues in lucine zipper proteins provides h ydrophobic interaction for dimerization (A) True...
Which of the following statements about chromatin remodeling is incorrect? Select one: O a. Chromatin remodeling provides the transcription machinery with dynamic access to an otherwise tightly packaged genome. O b. Chromatin remodeling often involves histone modifications (e.g., methylation). O c. Eukaryotes use chromatin remodeling as a mechanism for epigenetic modifications. O d. Prokaryotes use chromatin remodeling to regulate operon activity. O e. Chromatin remodeling plays a central role in the regulation of gene expression.
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