Question

Inflammation induces changes in the endothelial cells of the blood vessel inducing migration of immune cells from the blood vessels into the inflamed tissue. The process of migration is separated into four steps.

1. a) Provide a 1-2 sentence description for each step (rolling adhesion, tight binding, diapedesis, and migration).

2. b) What is the first innate cell type that migrates into the inflamed tissue? The second innate cell type?

3. c) What effector functions do these cells have that would make it beneficial to have fast recruitment in response to inflammation?

4. d) State 2 mechanisms that then allow resolution of this inflammation and tissue damage

Answer 1

1 Rolling adhesion t occurs during loukouyle exhawasahon). Leutoutes slow down & begin rolling along the inner surface of vessel wall, when carbohydrates liqcund in these leukocytice bind to selechin molecules. 2. Tight binding it occurs after rolling adhesion. In activated state, integuins bind tightly to complementary receptors expressed on endothelial cells, with high affinity. This cause immobilization d teukocytee 3. Diapedesis Major event in migrahon of leukocjtes from the blood circulation to the site of inflammation 4. Migrahon The process of movement of leukocyte from blood to site of inflammation. It requires tethering, rolling of leukocytes on endothelu m , arrest by activahon

are Ilic 2.b) Neubophits are most effective curoring the inflammation and cluoma phagocytosis process , Barophils coma and 36. Macrophages are the effector celle of innate immune system. They play important role in a host defense and inflammation .. Effector cello ore shoot lived, activated cells that defend the body in an immune respons, Elfector B cells are called plarma celli. They secrete antibodies. immune JULI