Question

Outline the differences between the Ras/MAPK pathway and the PI3K/Akt pathway. How are these pathways activated? What types o
0 0
Add a comment Improve this question Transcribed image text
Answer #1

Ras/MAPK pathway

PI3K/AKT pathway

Activation of Pathway

Binding of signalling molecule to the receptor on the cell surface

PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane

Molecules Involved

Ras (a Small GTPase)

MEK

MAP3K (e.g., Raf),

MAP2K,

MAPK (mitogen-activated protein kinases)

Myc (transcription factor)

PI3K

AKT

Consequence of Activation

Communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

Regulates the cell cycle and therefore, it directly controls cellular quiescence, proliferation, cancer, and longevity.

Differences:

  1. Ras/MAPK pathway accepts signal from the surface of the cell while PI3K/AKT pathway is an intracellular signalling pathway
Add a comment
Know the answer?
Add Answer to:
Outline the differences between the Ras/MAPK pathway and the PI3K/Akt pathway. How are these pathways activated?...
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions
ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT