would happen to the concentration of each of the following molecules: citrate, isocitrate, a-ketoglutarate, succinate, oxaloacetate,...
would happen to the concentration of each of the following molecules: citrate, isocitrate, a-ketoglutarate, succinate, oxaloacetate, malonate, ADP, and ATP in the experiment if you treated these mitochondria with excess amounts of malonate?
Homework Answers
yes, probably
Malonate is a competative inhibitor acted upon by succinate dehydrogenase (which is the enzyme?) If excess malonate were to act upon the citric acid cycle then the cycle would cease because it is an competative inhibitor and would eventually win over the substrate. Because the TCA cycle feeds further synthesis, stopping one site would stop all the others.
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would happen to the concentration of each of the
following molecules: citrate, isocitrate, a-ketoglutarate,
succinate, oxaloacetate,...
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d....
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...
Match the number with the letter. 1 Oxaloacetate ÇOO H-SCOA C00 Citrate C=0 CH2 HO-C-C00 16...
Match the number with the letter.
1 Oxaloacetate ÇOO H-SCOA C00 Citrate C=0 CH2 HO-C-C00 16 CHOICES: A. acetyl S-COA B. ADP C. ATP D. CO2 E. FAD F. FADH2 G. H20 H. NAD+ 1. NADH/Ht 1.02 K. H-SCOA 8 CH2 COO 14 13 CH2 COO BONUS 2.00 COO CH HC COO COO Isocitrate Malate HO-CH HO-CH CH2 COO 3 Citric acid cycle COO 7 2 3 15 4 СОЮ BONUS 6 COO 5 CH 11 HC Fumarate 7 &...
What type of gradient is critical to ATP formation by oxidativephosphorylation?A.sodium ionB....
What type of gradient is critical to ATP formation by oxidative phosphorylation?A.sodium ionB.chloride ionC.protonD.potassium ionE.None of the answers is correct.Which of the following citric acid cycle intermediates would become depleted if malonate, a competitive inhibitor of succinate dehydrogenase, were present?A.citrateB.α-ketoglutarateC.succinateD.malateE.None of the answers is correct.Which of the following correctly pairs a coenzyme with the enzyme of the pyruvate dehydrogenase complex with which it is associated?A.coenzyme A: pyruvate dehydrogenaseB.NAD+: dihydrolipoyl dehydrogenaseC.lipoic acid: pyruvate dehydrogenase kinaseD.thiamine pyrophosphate: dihydrolipoyl dehydrogenaseE.FAD: dihydrolipoyl transacetylaseWhich of...
In 1937 Hans Krebs deduced the operation of the citric acid cycle from careful observations on...
In 1937 Hans Krebs deduced the operation of the
citric acid cycle from careful observations on the oxidation of
carbon compounds in minced preparations of pigeon flight muscle.
(Pigeon breast is a rich source of mitochondria, but the function
of mitochondria was unknown at the time.) The consumption of O2 and
the production of CO2 were monitored with a manometer, which
measure changes in volume of a closed system at a constant pressure
and temperature. Standard chemical methods were used...
Question 2 (20 pts) In 1937 Hans Krebs deduced the operation of the citric acid cycle...
Question 2 (20 pts)
In 1937 Hans Krebs deduced the operation of the citric acid
cycle from careful observations on the oxidation of carbon
compounds in minced preparations of pigeon flight muscle. (Pigeon
breast is a rich source of mitochondria, but the function of
mitochondria was unknown at the time.) The consumption of O2 and
the production of CO2 were monitored with a manometer, which
measure changes in volume of a closed system at a constant pressure
and temperature. Standard...
In 1937 Hans Krebs deduced the operation of the citric acid cycle from careful observations on...
In 1937 Hans Krebs deduced the operation of the citric acid
cycle from careful observations on the oxidation of carbon
compounds in minced preparations of pigeon flight muscle. (Pigeon
breast is a rich source of mitochondria, but the function of
mitochondria was unknown at the time.) The consumption of O2 and
the production of CO2 were monitored with a manometer, which
measure changes in volume of a closed system at a constant pressure
and temperature. Standard chemical methods were used...
The common molecule produced from all foods at the second stage of catabolism is A) ADP. B acetyl...
just checking my answers, except for number 10.
The common molecule produced from all foods at the second stage of catabolism is A) ADP. B acetyl-CoA. C) glucose. D) citric acid. Which group of compounds includes only low-energy molecules? 1. 2. Hih A)ATP; acetyl-CoA; NADH; FADH2 C) ADP: CO2; NADH; FADH2 DONO BADP: acetyl-CoA; NAD+:FAD-mau ADP: CO2: NAD+, FAD After O2 has been reduced in the electron transport chain, the oxygen atoms are part of what molecules? A) ATP 3....
Which of the following is not a primary pump linking a transport reaction to a chemical...
Which of the following is not a primary pump linking a transport reaction to a chemical reaction? A. mitochondrial FoF1-ATP synthase, B. mitochondrial complex I, OC mitochondrial complex II, D. mitochondrial complex III, E mitochondrial complex IV, OF. all of the above How may c-subunits are believed to be present in the c-ring of mammalian mitochondria? DA.8. OB. OC. 12, OD. 14, OE 17, OF. none of the above. An enzyme's activity is analyzed using a Hill Plot and the...
- I believed the inhibited protein was ATP synthase, however the data on Figure 2 does...
- I believed the inhibited protein was ATP synthase, however the
data on Figure 2 does not support this. Please help!
The mitochondria from a patient suffering from muscle pain during physical exercises were analyzed to detect any defect in one of the components of the respiratory chain. Isolated mitochondria were incubated in an isotonic buffer, and changes in the oxygen consumption were measured as various components were sequentially added to the reaction. 1) The following graph (Fig. 1) shows...
1. You are studying an in vitro suspension of mitochondria that does not contain any NADH....
1. You are studying an in vitro suspension of mitochondria that does not contain any NADH. You run the experiment in a closed system with a set amount of oxygen; no new oxygen is introduced. (15pts) On the graph below, show the effect of adding fixed amounts of the following compounds at various times: • Time 1: ADP + Pi • Time 2: succinate (or any oxidizable substrate) • Time 3: oligomycin, an inhibitor of ATP synthase • Time 4:...
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...
Match the number with the letter.
1 Oxaloacetate ÇOO H-SCOA C00 Citrate C=0 CH2 HO-C-C00 16 CHOICES: A. acetyl S-COA B. ADP C. ATP D. CO2 E. FAD F. FADH2 G. H20 H. NAD+ 1. NADH/Ht 1.02 K. H-SCOA 8 CH2 COO 14 13 CH2 COO BONUS 2.00 COO CH HC COO COO Isocitrate Malate HO-CH HO-CH CH2 COO 3 Citric acid cycle COO 7 2 3 15 4 СОЮ BONUS 6 COO 5 CH 11 HC Fumarate 7 &...
In 1937 Hans Krebs deduced the operation of the
citric acid cycle from careful observations on the oxidation of
carbon compounds in minced preparations of pigeon flight muscle.
(Pigeon breast is a rich source of mitochondria, but the function
of mitochondria was unknown at the time.) The consumption of O2 and
the production of CO2 were monitored with a manometer, which
measure changes in volume of a closed system at a constant pressure
and temperature. Standard chemical methods were used...
Question 2 (20 pts)
In 1937 Hans Krebs deduced the operation of the citric acid
cycle from careful observations on the oxidation of carbon
compounds in minced preparations of pigeon flight muscle. (Pigeon
breast is a rich source of mitochondria, but the function of
mitochondria was unknown at the time.) The consumption of O2 and
the production of CO2 were monitored with a manometer, which
measure changes in volume of a closed system at a constant pressure
and temperature. Standard...
In 1937 Hans Krebs deduced the operation of the citric acid
cycle from careful observations on the oxidation of carbon
compounds in minced preparations of pigeon flight muscle. (Pigeon
breast is a rich source of mitochondria, but the function of
mitochondria was unknown at the time.) The consumption of O2 and
the production of CO2 were monitored with a manometer, which
measure changes in volume of a closed system at a constant pressure
and temperature. Standard chemical methods were used...
just checking my answers, except for number 10.
The common molecule produced from all foods at the second stage of catabolism is A) ADP. B acetyl-CoA. C) glucose. D) citric acid. Which group of compounds includes only low-energy molecules? 1. 2. Hih A)ATP; acetyl-CoA; NADH; FADH2 C) ADP: CO2; NADH; FADH2 DONO BADP: acetyl-CoA; NAD+:FAD-mau ADP: CO2: NAD+, FAD After O2 has been reduced in the electron transport chain, the oxygen atoms are part of what molecules? A) ATP 3....
Which of the following is not a primary pump linking a transport reaction to a chemical reaction? A. mitochondrial FoF1-ATP synthase, B. mitochondrial complex I, OC mitochondrial complex II, D. mitochondrial complex III, E mitochondrial complex IV, OF. all of the above How may c-subunits are believed to be present in the c-ring of mammalian mitochondria? DA.8. OB. OC. 12, OD. 14, OE 17, OF. none of the above. An enzyme's activity is analyzed using a Hill Plot and the...
- I believed the inhibited protein was ATP synthase, however the
data on Figure 2 does not support this. Please help!
The mitochondria from a patient suffering from muscle pain during physical exercises were analyzed to detect any defect in one of the components of the respiratory chain. Isolated mitochondria were incubated in an isotonic buffer, and changes in the oxygen consumption were measured as various components were sequentially added to the reaction. 1) The following graph (Fig. 1) shows...
1. You are studying an in vitro suspension of mitochondria that does not contain any NADH. You run the experiment in a closed system with a set amount of oxygen; no new oxygen is introduced. (15pts) On the graph below, show the effect of adding fixed amounts of the following compounds at various times: • Time 1: ADP + Pi • Time 2: succinate (or any oxidizable substrate) • Time 3: oligomycin, an inhibitor of ATP synthase • Time 4:...
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