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Why does alcohol increase the risk of overdose when taken in conjunction with many drugs of...

Why does alcohol increase the risk of overdose when taken in conjunction with many drugs of abuse, and yet contraindicate (diminish the effectiveness) of many prescription medications, such as antibiotics?

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Answer #1

Alcohol increases the risk of overdose when taken in conjunction with many drugs of such as codeine as it can, enhance their respective effects and increase the potential for a drug overdose. Alcohol inhibits the metabolism of codeine or other opioids, thereby increasing codeine's effects as it increases its half life.

Since the Potential side effects of antibiotics include:

  • nausea
  • sleepiness
  • dizziness
  • lightheadedness
  • diarrhea

Drinking alcohol can lead to an upset stomach and related digestive problems, hence enhance all theses side effects. Thus, combining alcohol and antibiotics can make all these symptoms more severe. This is especially true with certain types of antibiotics. Drugs such as trimethoprim-sulfamethoxazole and furazolidone can lead to more severe side effects if taken with alcohol.

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