2) What is the most likely phenotype of a loss of function mutation in a proto-oncogene?...
2) What is the most likely phenotype of a loss of function mutation in a proto-oncogene? (you may select more than one answer) a) Increased cell division b) decreased cell division c) cancer d) non-disjunction
Homework Answers
2) What is the most likely phenotype of a loss of function mutation in a proto-oncogene?
The correct option is ...............a) Increased cell division c) cancer
Proto-oncogenes can promote cell division through certain chemical messengers which act on the signal transduction and signal receptors between different cells during mitosis. They act as mitogens and gets involved in the protein synthesis. Once a mutation occurs in proto-oncogens, it changes the expression and activity of the hormones involved, proteins produced. Increased protein production leads to oncogene activity resulting in promoted growth and inactivation of tumour suppressor genes.
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2) What is the most likely phenotype of a loss of function
mutation in a proto-oncogene?...
Please let me know which of the following are right from question 1&2 1)What is the...
Please let me know which of the following are right from question 1&2 1)What is the most likely phenotype of a loss of function mutation in a proto-oncogene? (you may select more than one answer) Increased cell division, decreased cell division, cancer, non-disjunction QUESTION 2 Which of the following behaviors of meiotic chromosomes is responsible for Mendel's law of segregation? Condensation of chromosomes during metaphase 1 Segregation of homologous chromosomes during anaphase chromatids DNA replication in interphase Pairing of homologous...
Explain why a gain-of-function mutation to a proto-oncogene (or its promoter) may be associated with increased...
Explain why a gain-of-function mutation to a proto-oncogene (or its promoter) may be associated with increased risk of cancer. (b) Explain why a loss-of-function mutation to a tumor suppressor gene may be associated with increased risk of cancer.
13. Which of these statements is TRUE? a. Cancer cells usually have more than one mutation....
13. Which of these statements is TRUE? a. Cancer cells usually have more than one mutation. . Proto-oncogenes are normal genes that code for proteins that cause cells to undergo apoptosis (programmed cell death) c. Cancer usually involves a gain-of-function mutation in a tumor suppressor gene d. Cancer usually involves a loss-of-function mutation proto-oncogene
Which mutation is most likely to have a severe impact on the phenotype of an organism...
Which mutation is most likely to have a severe impact on the phenotype of an organism if it occurs within the first several bases of a gene coding region? A) a frameshift mutation of three nucleotides B) a missense mutation affecting one nucleotide C) a missense mutation affecting three nucleotides D) a silent mutation affecting one nucleotide E) a frameshift mutation of one nucleotide
Explain what classifies a mutation as “temperature‑sensitive” by comparing phenotype(s) with a wildtype allele. How is this type of phenotype explained by protein behaviour? Would the following typ...
Explain what classifies a mutation as “temperature‑sensitive” by comparing phenotype(s) with a wildtype allele. How is this type of phenotype explained by protein behaviour? Would the following types of mutations most likely have: severe effects, mild effects, or no effect on protein function? Briefly explain your answers. Note that there may be more than one correct answer, but you need only to give one sensible answer and explain your reasoning. [6 marks] A nonsense mutation occurring in sequences encoding amino...
Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A ge...
Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A gene that inhibits the transition from G1 to S phase c. d. A gene that promotes cell growth, combined with a hyperactive promoter How would methylation of the promoter of the gene in question 3c affect the cell? Be specific using what you know about the...
3) Proto-oncogenes can be converted to oncogenes by various genetic changes. Which of these mechanisms is...
3) Proto-oncogenes can be converted to oncogenes by various genetic changes. Which of these mechanisms is not likely to contribute to conversion to an oncogene? Select one: A: Extra copies of the gene are made, thereby enhancing expression. B: A mutation occurs upstream of the gene that results in a more active promoter. C: Chromosomes break and fragments are translocated from one chromosome to another. D: Point mutations occur that result in a protein more resistant to degradation. E: All...
1)Will a loss of function X-linked mutation ever confer a mutated phenotype, if carried on one...
1)Will a loss of function X-linked mutation ever confer a mutated phenotype, if carried on one of the X chromosomes of a female? Explain 2)Will you expect a null mutation in the gene encoding DNA Polymerase to be a lethal mutation? Why?
What would the most likely phenotype of an E. coli colony containing pUC18 (without an insert...
What would the most likely phenotype of an E. coli colony containing pUC18 (without an insert fragment) be if the following de novo mutations occurred early in the growth of a single cell into a colony on your plate (assuming plate contains X-gal, IPTG and Amp)? a. A frameshift mutation in the fifth codon lacZ gene in pUC18. b. A loss of the pUC18 plasmid. c. A deletion of bps at positions 19-25 of the ampicillin resistance gene open reading...
Help 45. A region of the chromosome 1000 base pairs upstream of the promoter for the...
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45. A region of the chromosome 1000 base pairs upstream of the promoter for the gene pbxH was deleted. This resulted in decreased expression of pbxH. This region is most likely a/an A. intron B. gene for a transcription factor C. gene for the RNA polymerase D. proximal control region E. enhancer 46. Methylation (actually, increased or hypermethylation) of the GSTP1 promoter is a common DNA alteration in certain cancers. Which of the following best characterizes this alteration? A....
Label the following as either proto-oncogene, oncogene or tumor suppressor 3. A gene that initiates apoptosis when DNA damage occurs a. b. A gene that initiates the transition from G1 to S phase A gene that inhibits the transition from G1 to S phase c. d. A gene that promotes cell growth, combined with a hyperactive promoter How would methylation of the promoter of the gene in question 3c affect the cell? Be specific using what you know about the...
Help
45. A region of the chromosome 1000 base pairs upstream of the promoter for the gene pbxH was deleted. This resulted in decreased expression of pbxH. This region is most likely a/an A. intron B. gene for a transcription factor C. gene for the RNA polymerase D. proximal control region E. enhancer 46. Methylation (actually, increased or hypermethylation) of the GSTP1 promoter is a common DNA alteration in certain cancers. Which of the following best characterizes this alteration? A....
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