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Cre-lox breeding: I need some help with terminology. Cre (+) (A2A^(flox/flox)) vs. Cre (-) (A2A^(flox/flox)). The...

Cre-lox breeding: I need some help with terminology.

Cre (+) (A2A^(flox/flox)) vs. Cre (-) (A2A^(flox/flox)). The A2A is just the receptor that they are knocking out in some mice.

I assumed that + meant that the receptor present and - meant it wasn't, but with the way the results read, it seems like the opposite? I am just finding the terminology very confusing.

Any help would be appreciated!

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Answer #1

Yes, sir, as you are considering (+), indicates the presence of the receptor and (-) means receptor is absent.

The following figure may help to better understand the phenomenon:

Image result for Cre-lox breeding (+) and (-) signs

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