Question

Problem Five One of the transducers in many growth factor signaling cascades is ras. a) How can mutations in ras (found in some types of cancers) contribute to transforming a normal cell into a tumor cell? b) Describe how ras plays a role in MAPK signaling pathways.

Answer 1

Auswes :- 1) vas į a proto - onwogene when it is mutated it is converted into an oncogene - Ras y active in it GTP form an incutive in its GDP form. upon growth fubor Jig milline Rag is converted to cutive GT p form which Enitiates the downsteam. Signalling Cascade leading to cell proliferation. a When the growth fator is removed Ras gets converted to incutive form. This inhibits the downsteam Signalling Cascade - A mutation usually a point mutation in ras increases its function. This overactivation of the ras gene and this Ray protein Continuously triggers the downstream sigualling cascade leading to abnormal proliferation of cells. Ras y locked in its active GTP. fhm whether growth fautor tal & presunt con ascut this contributes to the trausthmation of a normal cell into a tumor cell.

2 Ras MAPK pathway : - Signal pars from activated Ras to A Cascade of protein kinase, this cascade transmitter signals -downsteam from activated Ras protein to MAR Kinase Then the map kinase trans bocate this Signal to the moulues and activate transkriptional taulers. Dn please Rate my Answer it.