Question

I need answers for 13 to 15. Thank you

13. Deletion, Translocation, Inversion, Duplication, OR Mosaicism? Involved in 46, 5p- May result in a position effect which affects gene expression May result in pseudodominance of allele normally recessive to a dominant allele Two genetically distinct populations of cells in a single individual Will result in abnormal gamete formation (more than one answer) Involved in familial Down syndrome Lethal if it occurs in the same region of two homologous chromosomes No loss or gain of genetic material is involved (2 answers) Cell will have 45 chromosomes Increase of genetic material, may be tandem or reverse 46, XX 45. X (one individual) 14. Fill in the blanks on the pathway for phenylalanine metabolism. The arrows represent a mutant enzyme (and corresponding gene) that does not function in the pathway. phenylalanin Name of desse blocked crem 3.46 hydroxy phenylalanine blocked phydroxypheny Pyruvic acid blocked thyroxin b. Name of pigment 25 hydroxyphen! Pyruvic acid homogenisic blocked tonuria maleylacetoacetic acetic acid 15. List three possible modes of inheritance for this trait. Show your reasoning by indicating possible genotypes for each individual in each pedigree. 16. Before DNA sequences were available, the relationship between humans and other primates was supported by similarities between their chromosomes. The G-banding patter of chromosome 4 of humans and chimpanzees is shown below. What specific type of chromosomal change has occurred? (select from reciprocal translocation, interstitial deletion, pericentric inversion, paracentric inversion, robertsonian fusion, tandem duplication, reverse duplication) Huma Chimpanzee

Answer 1

13.

option b is correct answer

Inversion, deletion, may result in position effect that may affect gene expression.

14.

a. Name of disease phenylketonuria / PKU

b.name of pigment Melanin

Phenylalanine is a primary amino acid that is abundant in dietary protein. It's main metabolic pathway yields the amino acid Tyrosine, which is involved in the production of Melanin pigments. Defects of enzymes responsbile for interconversion of metabolites in the pathway are the cause of three well-studied, single-gene Inborn Errors of Metabolism: Phenylketonuria (PKU), Albinism (Melanin deficiency), and Alkaptonuria (excess HA).

15.PKU is an autosomal recessive metabolic genetic disorder. As an autosomal recessive disorder, two PKU alleles are required for an individual to experience symptoms of the disease. For a child to inherit PKU, both the mother and father must have and pass on the defective gene.