When cyanide is binded to the protein, Cytochrome C, the REMAINING (other) proteins of the ETC...
When cyanide is binded to the protein, Cytochrome C, the REMAINING (other) proteins of the ETC are ____?
a. in chronically oxidized state
b. in chronically reduced state
c. fluctuating between an oxidized & reduced state
After choosing the correct choice(a, b, or c), justify why that is the correct answer.
Homework Answers
The proteins are chronically reduced.
- Cyanide binds to complex IV in Electron transport chain.
- Cyanide ion interacts with the iron (Hem group) of the complex, acting as inhibitor of enzyme Cytochrome C Oxidase (aa3).
- Thus, cyanide blocks the electron flow, redox reactions and there will be no proton motive force generated causing stopping of ATP production.
- Cyanide thus also prevent electron flow from electron donors like NADH and FADH2.
- Thus, NADH cannot recycle to NAD+ resulting in increased NADH level and decreased NAD+ level.
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