(1)Compare the respective effect of HCl, on protein digestion by
pepsin, and on starch
digestion by amylase. Explain the physiological significance of
these effects in the human
digestive system.
(2)Explain how the digestion of fat can cause a drop in pH and
describe the functions of bile
salt.
Ans 1. HCl is major part of gastric juice secreted in lumen of stomach. Parietal/ Oxyntic cell in wall of stomach produce HCl.
HCl affects digestion in stomach in following ways:
1. HCl is strong acid and it keep pH of stomach around 1.5 to 3.5. At this acidic condition proteins are denatured and their peptide bonds are exposed for subsequent action of pepsin/ proteases.
2. HCl convert inactive proenzyme pepsinogen into active pepsinogen and inactive prorennin into active rennin in infants.
3. Pepsin hydrolyse proteins into peptide/ peptones in acidic medium provided by HCl.
4. But HCl inactivate the salivary amylase enzyme coming with food and hence stop the digestion of starch carbohydrates by salivary amylase in stomach.
5. Since stomach also produce gastric amylase and gastric lipase. Both these enzymes works in acidic medium and hence small amount of digestion of starch is carried out by gastric amylase in stomach and gastric lipase digest lipid in stomach in presence of HCl.
6. HCl also dissolve the hard substances present in food.
7. HCl kills the pathogens / microorganisms present with food.
Hence HCl helps in digestion of protein by pepsin in stomach but stop the digestion of starch by salivary amylase. Note: Small amount of starch is digested in stomach by gastric amylase.
Other physiological effects of HCl that excess amount of HCl in stomach cause avidity/ acid indigestion and heartburn. It also cause wounds in stomach wall if mucous layer damaged.
Note: Please submit second question separately.
(1)Compare the respective effect of HCl, on protein digestion by pepsin, and on starch digestion by...
Explain how the digestion of fat can cause a drop in pH and describe the functions of bile salt
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