Question

SIM with autoregulation: what is the effect of autoregulation in the master transcription factor Z in a SIM? plot schematically and compare the dynamics of the output genes in a given SIM with positive autoregulation of X, negative autoregulation of X and no autoregulation of X. Discuss when each design might be useful

Answer 1

ANSWER

Single input module (SIM): a master transcription factor X controls a group of target genes Z1,Z2,.........,Zn.Genes Zi in a SIM have a common biological function (For example they participate in a specific metabolic pathway).

SIM as a temporal expression program:genes Zi are activated one by one in defined order,based on different activation thresholds Ki of X for each of the target genes Zi.Thresholds K depends on the specific binding sites of X .These sites can be slightly different ,resulting in different K ifor each Zi

When the activily level of X changes gradually in time ,it crosses the thresholds Ki at different times and the genes Zi are turned ON/OFF in the implied order .when the level of X first goes up and then comes down,the genes Zi are affected in the last in first out (LIFO)

Answer 2

ANSWER

Single input module (SIM): a master transcription factor X controls a group of target genes Z1,Z2,.........,Zn.Genes Zi in a SIM have a common biological function (For example they participate in a specific metabolic pathway).

SIM as a temporal expression program:genes Zi are activated one by one in defined order,based on different activation thresholds Ki of X for each of the target genes Zi.Thresholds K depends on the specific binding sites of X .These sites can be slightly different ,resulting in different K ifor each Zi

When the activily level of X changes gradually in time ,it crosses the thresholds Ki at different times and the genes Zi are turned ON/OFF in the implied order .when the level of X first goes up and then comes down,the genes Zi are affected in the last in first out (LIFO)

single input module (SIM) Z1 Z2 ... Zn arg агдсөн, arge argF. B.s