What is the difference between how lipid soluble drugs and water soluble drugs get excreted by...
What is the difference between how lipid soluble drugs and water soluble drugs get excreted by the kidney? Can they both be excreted by the kidneys and why?
Homework Answers
Water soluble (hydrophilic) drugs are easily excreted via the kidney, where lipid soluble (lipophilic) drugs require further metabolism at the liver before being excreted via bile or kidney. Lipid soluble drugs are reabsorbed from the renal tubules and transported back to the liver. These lipid-soluble drugs undergo various modifications like conjugation with glucuronide in the liver and excreted via the bile-gut-feces route. If they are still sufficiently lipid-soluble, they will be transported back to the liver via the entero-hepatic circulation for further metabolism.
So, the water-soluble drugs are excreted via the kidneys, while the lipid-soluble drugs are excreted in the feces.
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