Question

can you guys please give me the correct answers and explain why?

9. Which of the following statements is INCORRECT? A. Most human cells contain high levels of telomerase. B. Telomeres protect the ends of eukaryotic chromosomes. C. Telomerase is ribonucleoprotein D. Each round of replication shortens eukaryotic chromosomes. E. Telomerase is an RNA-dependent DNA polymerase. 10. DNA in front of the replication fork is positively supercoiled (over-wound). What is the source of energy required for this over-winding? Pollll Core Polymerase and deoxynucleotides B. Gyrase and ATP C. The clamp loader and ATP D. DnaA and ATP E. Helicase and ATP 11. Misincorporation of a nucleotide during replication can lead to a transition mutation Which of the following statements concerning such a mutation is correct? A. If the mutation occurs in a protein coding region of the DNA, the mRNA made from the gene will be recognized as defective and will be rapidly degraded. B. If the mutation occurs in a protein coding region of the DNA, it will not necessarily lead to the production of an inactive protein. C. If the mutation occurs in a region of the genome that is transcribed it will probably be recognized by RNA polymerase and transcription will terminate at the site of the mutation D. If the mutation occurs in a protein coding region of the DNA it will probably result in a frameshift during translation which will cause translation to terminate. E. If the mutation occurs in a protein coding region of the DNA the probability that it will create a stop codon is approximately 64%.

Answer 1

QUESTION 9: Telomeres - during DNA replication, part of DNA at the very end of the eukaryotic chromosomes cannot be fully copied in each replication, leaving a single stranded overhang, resulting in gradual shortening of the chromosomes. As the chromosome end wears down, to prevent this loss, the tip of the eukaryotic chromosomes have telomeres.

Telomerase is a ribonucleoprotein or RNA-dependent DNA polymerase i.e its an enzyme that using RNA as a template can make DNA. At the 3' end of telomeres, It adds a species dependent sequence of telomere repeat.

THEREFORE, the options B, C, D and E all are correct statement.

Hence , the incorrect one is (a).