Question

PROBLEMS Using the information below, construct a pedigree in the space provided and answer the following questions. Nick and Nora have come to a genetic counselor to determine their chances of having a child with Huntington's disease, a late-in-life degenerative neurological disorder that is inherited with the autosomal dominant allele H. The autosomal recessive allele h does not contribute to the development of the disease. Neither Nick nor Nora neither show any signs of the disease at present. Nick's paternal grandfather (his father's father) died of Huntington's disease. Nick's grandfather's mother (Nick's great-grandmother) did not have disease. There is no history of Huntington's Disease in Nora's family or in Nicks mother's or paternal grandmother's (his father's mother) family. a. Draw the pedigree that shows the familial relationships described in the paragraph above. What is the probability that Nick is a carrier of the Hallele? c. What is the probability that Nick and Nora will have a child with Huntington's disease?

Answer 1

3 H D-1 -> Mick IV-2 Nora 5 67 b) Prob. that Nick is a carrier. Nick GV-1) is a carrier, if he recieved the Hallele from his grandfather via his father. prob. of t transmitted from I-1 to I-1 = 1 (since Mick's great-grand mother did not have - , from 9 - 1 to I-1 (Nick) Huntington's his grandfather -1/2 x==1/4 is Heterozygous). :. Probability that Mick is a carrier is 0.25 (or 1/4) Proba. that Mick & Mora will have a child with Hunting for's = Pro that fick is a Carrier & 1/2 = 1/2 x 1 = 1/8 2. Probability = 0.125 c)