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The central vulval precursor cells laterally inhibits two cells (presumptive lateral vulval precursors) on either side,...

The central vulval precursor cells laterally inhibits two cells (presumptive lateral vulval precursors) on either side, from becoming central vulval precursor cells using Notch signaling. Therefore eliminating Notch signaling specifically from the two “presumptive” lateral vulval precursor cells will:

A. result in 3 lateral vulval precursor cells

B. result in 3 central vulval precursor cells

C. result in no central vulval precursor cell

D. result in 2 lateral vulval precursor cells

E. none of the above

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Answer #1

Correct ans is B

Reason: Removal of NOTCH signalling from lateral or secondary valval precursor cell will result - formation of 3 central valval precursor cell, because LIN 3 will now equally act on all three cells P5.p, P6.p and P7.p cells i.e. it will result total (8+8+8) or 24 vulval cells. Loss of NOTCH signalling DO NOT activate LIN 12.Anchor cell LIN 13 ---- - Po.P P4.p psipt Phip - signal i activates LIN-12 P7.p Signal activates LIN-12 1. 2° Lateral cantral

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