Question

Mutations in the gene that codes for the protein P53 are linked to cancer because: Changes to the shape of P53 can result in growth factor receptors that continue to signal even when there are no growth factors present Changes to the shape of P53 can result in a protein that replicates DNA all the time, not just during S phase Changes to the shape of P53 can prevent growth factor receptors from receiving signals Changes to the shape of P53 can prevent it from stopping replication of damaged DNA

Answer 1

Mutations in the gene that codes for the protein P53 are linked to cancer because-

Changes to the shape of P53 can prevent it from stop replication of damaged DNA.

The altered p53 protein cannot regulate cell growth and division and is unable to trigger apoptosis in cells with mutated or damaged DNA as a result DNA damage can accumulate in cells.

There are two types of gene that are responsible in the development and growth of cancers : oncogenes & tumor supressor genes.

p53 is a protein whose main function is to repair DNA in order to prevent altered DNA to be passed on to daughter cells. When the damage in DNA is too extensive to be repaired ,p53 signal cells to undergo apoptosis.