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describe the activation cycle of a trimeric G protein.

describe the activation cycle of a trimeric G protein.

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Answer #1

Guanine nucleotide - binding proteins is known as G protein. In the resing state ,the G protein is trimeric(G a GDP G beta gamma) that is occupied byGDP.GPCRs interact with resting (GDP- bound) G- proteins,facilitate the GDP release and stablize an empty G protein conformation.G a GTP hydrolyses GTP to GDP and the G a GDP complex recognizes G beta gamma with a very high affinity: the resting trimeric complex reforms spontaneously.

GTP hydrolysis can be accelerated by "Regulators of G protein Signalling"(RGS) molecules.

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